Director of Toxicology & Preclinical Pharmacology
We are seeking a highly motivated and experienced Director of Toxicology & Preclinical Pharmacology to lead our drug discovery and development programs. As the Director of Toxicology & Preclinical Pharmacology, you will play a pivotal role in advancing our research and development efforts by providing expert guidance on drug metabolism and pharmacokinetics. You will be responsible for overseeing toxicology studies, preclinical pharmacological evaluations, and ensuring the safety and efficacy of potential drug candidates.
Leadership and Strategy: Lead and manage the Toxicology & Preclinical Pharmacology team, providing clear direction and guidance on drug discovery and development projects. Develop and execute a comprehensive strategy for preclinical evaluation, considering drug metabolism, pharmacokinetics, and safety assessment.
Drug Metabolism and Pharmacokinetics (DMPK): Utilize your expertise in DMPK to evaluate and optimize the ADME (absorption, distribution, metabolism, and excretion) properties of drug candidates. Collaborate with medicinal chemistry and other teams to design compounds with improved pharmacokinetic profiles.
Preclinical Safety Assessment: Oversee and conduct in vitro and in vivo toxicology studies to assess the safety profile of drug candidates. Interpret and communicate toxicological findings to cross-functional teams and senior management.
Efficacy Evaluation: Design and oversee preclinical pharmacology studies to evaluate the efficacy and mechanism of action of potential drug candidates. Utilize relevant animal models and endpoints to assess the therapeutic potential of new compounds.
Regulatory Compliance: Ensure compliance with regulatory guidelines and industry standards for preclinical safety and pharmacological evaluations. Collaborate with regulatory affairs to prepare relevant documentation for regulatory submissions.
Cross-functional Collaboration: Work closely with multidisciplinary teams, including medicinal chemistry, biology, pharmacology, and clinical development, to provide toxicological and DMPK expertise throughout the drug development process.